ABSTRACT
Background and Aim: Despite the use of different drugs in the treatment of bipolar disorder, about 50 percent of the patients are not completely cured. To strengthen the treatment effect, various medications including new antiepileptic drugs and serotonin-dopamine antagonists have been studied. Considering the potential role of NMDA receptor antagonists on the mood changes, this study was conducted to investigate the effects of memantine on acute mania as an adjunctive therapy to lithium and risperidone
Material and Method: Our study was a double-blind randomized clinical trial which included 40 patients with bipolar disorder in the acute phase of mania. Patients in both groups were treated with the same drug regimen [including risperidone and lithium]. In the intervention group, an oral dose of memantine, 5 mg/day was started and increased to 20 mg / day after 96 hours. Patients in the control group received placebo. Severity of the symptoms before starting treatment and at the 1st, 2nd, 4th and 6th weeks after treatment was measured based on the Young Mania Rating Scale. We estimated clinical side effects of memantine by using a clinical check list
Results: At the end of the study, severity of manic symptoms decreased in both groups, but speed and rate of reduction of the symptoms of mania were not significantly different in the memantine group compared with the placebo group [p=0.784]. The most common side effects in both groups included; restlessness [p=1.000], tremor [p=0.501], and dizziness [p=0.605], which were not significantly different in both groups
Conclusion: Considering the limitations such as small sample size and short period of the study, addition of memantine 20 mg /day to the treatment regimen of the patients with bipolar disorder in the manic phase, for six weeks, had no effect on the rate and extent of symptoms of mania
ABSTRACT
Introduction: Since Anger and Violence is a major problem for public health and social and economic and social costs of aggressive behavior are high and considerable in order to develop prevention programs, especially aggression in public places is necessary to evaluate rates and the factors influencing
Purpose: The aim of the current research was to determine of the Personality Disorders and clinical signs in aggression attempter in the Public Places of sanandaj City
Method: This research was a descriptive study, targeting all Aggression attempter referred to the commissariat due to aggression attempt in Public Places of sanandaj City that were selected 102 attempter [87 males and 15 females] by convenience sampling. Data were collected by Demographic questionnaire and Millon Multi-axial personality inventory-III [MCMI-III]. The data were analyzed by SPSS and used the MANOVA
Results: results showed that the highest personality disorders respectively include of Hystrionic, narcissist, depression and lowest include of dependence, schizotypal, avoidance, passive- aggression. the highest clinical disorders respectively include of dysthymia, Thought disorder, major depression, and the lowest include of Delusion Disorder and PTSD. There was significant difference between two groups in the all personality disorders except passive aggression, obsessive-compulsion and in the all clinical disorders except PTSD and somatoform [p
Conclusion: The findings of this study can be helpful in identifying and preventing aggression in the Public Places as Social problem